{"product_id":"m21790","title":"SB-399885 hydrochloride","description":"\u003cp style=\"padding-left:1em;\"\u003eSB-399885 hydrochloride is a 5-HT6 receptor antagonist.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eProduct information\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 402713-81-9\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 482.81\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eFormula:\u003c\/strong\u003e C18H22Cl3N3O4S\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eChemical Name:\u003c\/strong\u003e N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-(piperazin-1-yl)benzene-1-sulfonamide hydrochloride\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eSmiles:\u003c\/strong\u003e Cl.COC1C=CC(=CC=1N1CCNCC1)S(=O)(=O)NC1=CC(Cl)=CC(Cl)=C1OC\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eInChiKey:\u003c\/strong\u003e RNKCEBCFUSXSQE-UHFFFAOYSA-N\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eInChi:\u003c\/strong\u003e InChI=1S\/C18H21Cl2N3O4S.ClH\/c1-26-17-4-3-13(11-16(17)23-7-5-21-6-8-23)28(24,25)22-15-10-12(19)9-14(20)18(15)27-2;\/h3-4,9-11,21-22H,5-8H2,1-2H3;1H\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTechnical Data\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAppearance:\u003c\/strong\u003e Solid Power\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (or refer to the Certificate of Analysis)\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e DMSO : 100 mg\/mL (207.12 mM; Need ultrasonic). H2O : 6.67 mg\/mL (13.81 mM; ultrasonic and warming and heat to 60°C).\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eShipping Condition:\u003c\/strong\u003e Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eStorage Condition:\u003c\/strong\u003e Dry, dark and -20 \u003csup\u003eo\u003c\/sup\u003eC for 1 year or refer to the Certificate of Analysis.\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eShelf Life:\u003c\/strong\u003e ≥12 months if stored properly.\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eStock Solution Storage:\u003c\/strong\u003e 0 - 4 \u003csup\u003eo\u003c\/sup\u003eC for 1 month or refer to the Certificate of Analysis.\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eDrug Formulation:\u003c\/strong\u003e To be determined\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eHS Tariff Code:\u003c\/strong\u003e 382200\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eHow to use\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eIn Vivo:\u003c\/strong\u003e\u003c\/p\u003e\u003cp style=\"padding-left:1em;\"\u003eCompare with the control vehicle SB-399885 hydrochloride 10 mg\/kg significantly increases wakefulness (W) (F(3,15)=3.32, P\u0026lt;0.05) while slow wave sleep (SWS), rapid-eye-movement sleep (REMS) and the number of REM periods are reduced (F(3,15)=4.0, P\u0026lt;0.01; F(3,15)=3.14, P\u0026lt;0.05 and F(3,15)=2.62, P\u0026lt;0.05, respectively). Analysis of sleep variables in 2-h blocks shows that SB-399885 hydrochloride 10 mg\/kg increases W (F(3,15)=5.48, P\u0026lt;0.01) and reduces SWS (F(3,15)=5.42, P\u0026lt;0.01) and REMS (F(3,15)= 4.05, P\u0026lt;0.01) during the first 2-h period. SB-399885 hydrochloride 5 and 10 mg\/kg augment light sleep over the first (F(3,15)=3.46,P\u0026lt;0.01 and F(3,15)= 3.65, P\u0026lt;0.01, respectively) and the second (F(3,15)=3.23, P\u0026lt;0.05 and F(3,15)=3.08, P\u0026lt;0.05, respectively) 2-h recording periods. SB-399885 hydrochloride 10 mg\/kg significantly increases REMS latency (F(3,15)=3.60, P\u0026lt;0.01) and reduces the number of REM periods during the first 2-h of recording (F(3,15)=3.88, P\u0026lt;0.01).\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eProducts are for research use only. Not for human use.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Xcess Biosciences","offers":[{"title":"M21790-C \/ Contact sales@xcessbio.com for quotation","offer_id":39524667818123,"sku":"0","price":100.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0389\/1897\/9723\/products\/M21790_1635222413.gif?v=1635222414","url":"https:\/\/www.xcessbio.com\/products\/m21790","provider":"Xcess Biosciences","version":"1.0","type":"link"}