LY3177833


Catalog No. Size PriceQuantity
M21843-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

LY3177833 is a CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively.

Product information

CAS Number: 1627696-51-8

Molecular Weight: 309.30

Formula: C16H12FN5O

Chemical Name: (3R)-3-(5-fluoropyrimidin-4-yl)-3-methyl-6-(1H-pyrazol-4-yl)-2,3-dihydro-1H-isoindol-1-one

Smiles: C[C@]1(NC(=O)C2C=C(C=CC1=2)C1=CNN=C1)C1=NC=NC=C1F

InChiKey: KNLVLWZENYQYRT-MRXNPFEDSA-N

InChi: InChI=1S/C16H12FN5O/c1-16(14-13(17)7-18-8-19-14)12-3-2-9(10-5-20-21-6-10)4-11(12)15(23)22-16/h2-8H,1H3,(H,20,21)(H,22,23)/t16-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 30 mg/mL (96.99 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

LY3177833 (Compound example 4; 10.4-31.2 mg/kg; oral gavage; twice a day; for 2 weeks; female athymic Balb/c nude mice with SW620 cells) treatment causes significant tumor regression in a dosedependent manner. Also, no significant tumor growth is observed for 2 weeks after dosing cessation.

Products are for research use only. Not for human use.

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