SX-682


Catalog No. Size PriceQuantity
M21861-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

SX-682 is an orally bioavailable, potent allosteric inhibitor of CXCR1 and CXCR2. SX-682 can block tumor myeloid-derived suppressor cells (MDSCs) recruitment and enhance T cell activation and antitumor immunity.

Product information

CAS Number: 1648843-04-2

Molecular Weight: 467.20

Formula: C19H14BF4N3O4S

Chemical Name: {2-[({5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl}sulfanyl)methyl]-4-(trifluoromethoxy)phenyl}boronic acid

Smiles: OB(O)C1=CC=C(C=C1CSC1N=CC(=CN=1)C(=O)NC1=CC=C(F)C=C1)OC(F)(F)F

InChiKey: SDUDZBCEHIZMFZ-UHFFFAOYSA-N

InChi: InChI=1S/C19H14BF4N3O4S/c21-13-1-3-14(4-2-13)27-17(28)12-8-25-18(26-9-12)32-10-11-7-15(31-19(22,23)24)5-6-16(11)20(29)30/h1-9,29-30H,10H2,(H,27,28)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (535.10 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

SX-682 (50 mg/kg; orally; twice a day on a Monday through Friday) has Meager to moderate effects as single agents on CRPC progression was observed, yet combination with ICB produced strong efficacy.

Products are for research use only. Not for human use.

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