Hydroxy Bupropion


Catalog No. Size PriceQuantity
M22280-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Buproprion is an inhibitor of the reuptake of dopamine and norepinephrine and is also an antagonist of neuronal acetylcholine nicotinic receptors. Because of its effects on nicotinic receptors, it is used to promote smoking cessation. Hydroxy bupropion is a mixture of enantiomers produced by the metabolism of buproprion by cytochrome P450 2B6. Compared with buproprion, this racemic mixture produces equal inhibition of norepinephrine reuptake (IC50 = 1.7 µM) and much weaker inhibition of dopamine reuptake (IC50 >10 µM). Moreover, hydroxyl bupropion isomers are potent antagonists of nicotinic receptors, suggesting that they may substitute for bupropion in smoking cessation.

Product information

CAS Number: 357399-43-0

Molecular Weight: 255.74

Formula: C13H18ClNO2

Chemical Name: 2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol

Smiles: CC1(C)COC(O)(C(C)N1)C1C=C(Cl)C=CC=1

InChiKey: RCOBKSKAZMVBHT-UHFFFAOYSA-N

InChi: InChI=1S/C13H18ClNO2/c1-9-13(16,17-8-12(2,3)15-9)10-5-4-6-11(14)7-10/h4-7,9,15-16H,8H2,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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