Methiothepin maleate

Catalog No. Size PriceQuantity
M22296-C Contact for quotation $100Unavailable


Methiothepin is a non-selective antagonist of the serotonin (5-HT) receptor. It is a potent antagonist of 5-HT1A and 5-HT1B (IC50 = 16 nM and Ki = 0.2 nM, respectively) as well as 5-HT2A, 5-HT2B, and 5-HT2C receptors (Kis = 3.16, 2.08, and 4.46 nM, respectively).,, Methiothepin binds to 5-HT5A, 5-HT5B, 5-HT6, and 5-HT7 receptors with Kd values of 100, 15.8, 1.8, and 1 nM, respectively.1 It has been used to characterize the role of serotonin in various biological processes, including renal vasodilation and gastrointestinal function.,

Product information

CAS Number: 19728-88-2

Molecular Weight: 472.62

Formula: C24H28N2O4S2

Chemical Name: (2Z)-but-2-enedioic acid; 1-methyl-4-[(9R)-6-(methylsulfanyl)-2-thiatricyclo[³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-9-yl]piperazine

Smiles: CN1CCN(CC1)[C@@H]1CC2=CC=CC=C2SC2=CC=C(C=C21)SC.OC(=O)/C=C\C(O)=O


InChi: InChI=1S/C20H24N2S2.C4H4O4/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20;5-3(6)1-2-4(7)8/h3-8,14,18H,9-13H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t18-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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