Description
IC50: 140 nM ML-354 is an indole-based, proteinase-activated receptor (PAR) 4 antagonist with good potency and reasonable selectivity versus PAR1. PARs are a family of four G-protein-coupled receptors GPCRs (PAR1-PAR4) with several unique attributes, which are activated by serine proteases. The activation of PARs needs a unique mechanism which requiring proteolysis unmasking their extracellular N-terminal domain. PAR4 is a thrombin receptor found on human platelets and represents a potential therapeutic target for the treatment of thrombotic disorders . In vitro: Up to now, in vitro study of ML-354 is still in the development stage. In vivo: Up to now, in vivo study of ML-354 is still in the development stage.
Product information
CAS Number: 89159-60-4
Molecular Weight: 282.29
Formula: C16H14N2O3
Chemical Name: (1-methyl-5-nitro-3-phenyl-1H-indol-2-yl)methanol
Smiles: CN1C(CO)=C(C2C=C(C=CC1=2)[N+]([O-])=O)C1C=CC=CC=1
InChiKey: GNJUKVGDCUKDLF-UHFFFAOYSA-N
InChi: InChI=1S/C16H14N2O3/c1-17-14-8-7-12(18(20)21)9-13(14)16(15(17)10-19)11-5-3-2-4-6-11/h2-9,19H,10H2,1H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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