Thienyldecyl Isothiocyanate


Catalog No. Size PriceQuantity
M22600-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Thienyldecyl isothiocyanate is a cytochrome P450 inhibitor . The human cytochrome P450 (CYP), a cellular chromophore, has been implicated in metabolism of drugs, arachidonic acid, foreign chemicals, and eicosanoids; steroid synthesis and metabolism; vitamin D3 synthesis and metabolism; cholesterol metabolism and bile-acid biosynthesis; retinoic acid hydroxylation. Until now, there are more than 270 different CYP gene families have been identified, with 18 recorded in mammals. It has been repoted that cytochrome P450 is now understood to include a myriad of enzymic reactions implicated in important life processes. Mutations in many CYP genes result in inborn errors of metabolism and contribute to many clinically relevant diseases . Thienyldecyl isothiocyanate was an analog of thienylbutyl isothiocyanate. Thienyldecyl isothiocyanate showed antiproliferative activity against cancer cells presumably that, like many isothiocyanates. Thienyldecyl isothiocyanate functioned by modulation of xenobiotic-metabolizing enzymes, such as by inhibition of cytochrome P450, and/or by induction of phase II detoxifying enzymes .

Product information

CAS Number: 288323-41-1

Molecular Weight: 281.48

Formula: C15H23NS2

Chemical Name: 2-(10-isothiocyanatodecyl)thiophene

Smiles: S=C=NCCCCCCCCCCC1=CC=CS1

InChiKey: QRGUKFSTCYZBKD-UHFFFAOYSA-N

InChi: InChI=1S/C15H23NS2/c17-14-16-12-8-6-4-2-1-3-5-7-10-15-11-9-13-18-15/h9,11,13H,1-8,10,12H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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