Catalog No. Size PriceQuantity
M22749-C Contact for quotation $100Unavailable


ML-031 is an agonist of S1P2 with EC50 value of 1 μM . Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid mediator mainly released from activated platelets and implicated in many biological responses, such as cell proliferation, migration, survival, and differentiation . Sphingolipids belong to a family of bioactive molecules with cell signaling properties. Sphingosine 1-phosphate (S1P) is widely expressed on various tissues and cell types. S1P is a pleiotropic lysophospholipid mediator exists in plasma and is released in large amounts from activated platelets . Until now, five sphingosine-1-phosphate receptors (S1PR1-S1PR5) have been identified. S1PR4 and S1PR5 are prominently expressed in the immune and nervous systems, respectively. S1P functions by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. ML-031 activated S1P2 with an EC50 value of 1 μM in a S1P reporter assay .

Product information

CAS Number: 852230-33-2

Molecular Weight: 324.37

Formula: C19H20N2O3

Chemical Name: 1-[2-(1-benzyl-2,5-dimethyl-1H-pyrrol-3-yl)-2-oxoethyl]pyrrolidine-2,5-dione

Smiles: CC1=C(C=C(C)N1CC1C=CC=CC=1)C(=O)CN1C(=O)CCC1=O


InChi: InChI=1S/C19H20N2O3/c1-13-10-16(17(22)12-21-18(23)8-9-19(21)24)14(2)20(13)11-15-6-4-3-5-7-15/h3-7,10H,8-9,11-12H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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