Papain Inhibitor

Catalog No. Size PriceQuantity
M22807-C Contact for quotation $100Unavailable


Papain Inhibitor peptide,(C19H29N7O6),a peptide with the sequence H-Gly-Gly-Tyr-Arg-OH,MW= 451.4,this peptide Inhibits the peptidase activity of Papain. Papain,also known as papaya proteinase I,is a cysteine protease enzyme present in papaya and mountain papaya. The mechanism by which it breaks peptide bonds involves deprotonation of Cys-25 by His-159. Asparagine-175 helps to orient the imidazole ring of His-159 to allow this deprotonation to take place. Cys-25 then performs a nucleophilic attack on the carbonyl carbon of a peptide backbone. This frees the amino terminal of the peptide,and forms a covalent acyl-enzyme intermediate. The enzyme is then deacylated by a water molecule,and releases the carboxy terminal portion of the peptide. In immunology,papain is known to cleave the Fc (crystallisable) portion of immunoglobulins (antibodies) from the Fab (antigen-binding) portion1. Papain prefers to cleave at: (hydrophobic) -(Arg or Lys)- cleaves here -(not Val). Hydrophobic is Ala,Val,Leu,Ile,Phe,Trp,or Tyr2. Papain can be used to dissociate cells in the first step of cell culture preparations. It is also used as an ingredient in various enzymatic debriding preparations,notably Accuzyme. These are used in the care of some chronic wounds to clean up dead tissue.Papain can also be found as an ingredient in some toothpastes or mints as teeth-whitener.

Product information

CAS Number: 70195-20-9

Molecular Weight: 451.48

Formula: C19H29N7O6

Chemical Name: 2-{2-[2-(2-aminoacetamido)acetamido]-3-(4-hydroxyphenyl)propanamido}-5-[(diaminomethylidene)amino]pentanoic acid

Smiles: NC(N)=NCCCC(NC(=O)C(CC1C=CC(O)=CC=1)NC(=O)CNC(=O)CN)C(O)=O


InChi: InChI=1S/C19H29N7O6/c20-9-15(28)24-10-16(29)25-14(8-11-3-5-12(27)6-4-11)17(30)26-13(18(31)32)2-1-7-23-19(21)22/h3-6,13-14,27H,1-2,7-10,20H2,(H,24,28)(H,25,29)(H,26,30)(H,31,32)(H4,21,22,23)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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