{"product_id":"m22875","title":"SB 205384","description":"\u003cp style=\"padding-left:1em;\"\u003eSB-205384 is a selective and positive GABAA receptor modulator with EC50 values of 280, 695 and 730 nM on α6, α3 and α5-subunit-containing receptors, respectively . g-Aminobutyric acid (GABA) acting on the GABAA receptor can inhibit synaptic transmission in the mammalian central nervous system . Ligands that modulate the function of g-aminobutyric acid A (GABAA) receptor gated chloride channels have hypnotic, anaesthetic, anxiolytic, anticonvulsant and sedative actions . SB-205384 can slow the decay rate on GABAA currents in oocytes expressing human GABAA subunits, which is also seen on native GABA-activated currents in rat neurons . The isoforms containing the a3, a5, and a6 subunits show significantly greater enhancement of the current by SB-205384 and the receptors with the a6-subunit had the greatest sensitivity to SB-205384 . In rat cerebellum granule cells, SB-205384 dramatically pro-longed the half-life for decay of the GABA response in a concentration-dependent manner. The half-life of decay was increased about 10 fold compared with control responses at the highest concentration of SB-205384 used. Also, SB-205384 did not increase the maximum current evoked by 100 mM GABA but the half-life decay was dramatically increased, as saw at the lower dose of 1 mM GABA .\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eProduct information\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 160296-13-9\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 330.40\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eFormula:\u003c\/strong\u003e C17H18N2O3S\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eChemical Name:\u003c\/strong\u003e but-2-yn-1-yl (11S)-3-amino-11-hydroxy-5-methyl-8-thia-6-azatricyclo[7.4.0.0²,⁷]trideca-1(9),2,4,6-tetraene-4-carboxylate\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eSmiles:\u003c\/strong\u003e CC1N=C2SC3C[C@@H](O)CCC=3C2=C(N)C=1C(=O)OCC#CC\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eInChiKey:\u003c\/strong\u003e JDTZAGLGBRRCJT-JTQLQIEISA-N\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eInChi:\u003c\/strong\u003e InChI=1S\/C17H18N2O3S\/c1-3-4-7-22-17(21)13-9(2)19-16-14(15(13)18)11-6-5-10(20)8-12(11)23-16\/h10,20H,5-8H2,1-2H3,(H2,18,19)\/t10-\/m0\/s1\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTechnical Data\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAppearance:\u003c\/strong\u003e Solid Power\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (or refer to the Certificate of Analysis)\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eShipping Condition:\u003c\/strong\u003e Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eStorage Condition:\u003c\/strong\u003e Dry, dark and -20 \u003csup\u003eo\u003c\/sup\u003eC for 1 year or refer to the Certificate of Analysis.\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eShelf Life:\u003c\/strong\u003e ≥12 months if stored properly.\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eStock Solution Storage:\u003c\/strong\u003e 0 - 4 \u003csup\u003eo\u003c\/sup\u003eC for 1 month or refer to the Certificate of Analysis.\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eDrug Formulation:\u003c\/strong\u003e To be determined\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eHS Tariff Code:\u003c\/strong\u003e 382200\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eProducts are for research use only. Not for human use.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Xcess Biosciences","offers":[{"title":"M22875-C \/ Contact sales@xcessbio.com for quotation","offer_id":39527675560075,"sku":"0","price":100.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0389\/1897\/9723\/products\/M22875_1635331757.gif?v=1635331759","url":"https:\/\/www.xcessbio.com\/products\/m22875","provider":"Xcess Biosciences","version":"1.0","type":"link"}