Trimidox


Catalog No. Size PriceQuantity
M23083-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Trimidox (3.4.5-tri-hydroxybenzohydroxamidoxime) is a specific and patented ribonucleotide reductase (RNR) inhibitor . Ribonucleotide reductase (RNR), also known as ribonucleoside diphosphate reductase, is an enzyme involved in catalyzing the formation of deoxyribonucleotides from ribonucleotides. RNR plays a vital role in regulating the total rate of DNA synthesis to DNA to maintain DNA cell mass a constant ratio during cell division and DNA repair. The substrates for RNR are ADP, GDP, CDP and UDP . Increased ribonucleotide reductase (RNR) activity has been associated with malignant transformation and tumor cell growth . In human promyelocytic leukemia HL-60 cells, trimidox inhibited the growth of with an IC50 of 35 pmol/L. Treatment with trimidox (50 pmol/L) for 24 hours decreased deoxyguanosine triphosphate (dGTP) and deoxycytidine triphosphate (dCTP) pools to 24% and 3946 of control values, respectively. Incubation of HL-60 cells with 20 to 80 pmol/L trimidox to 4 days showed no effects in the distribution of cells indifferent phases of cell cycle . Trimidox in combination with tiazofurin was useful in the treatment of leukemia .

Product information

CAS Number: 95933-74-7

Molecular Weight: 184.15

Formula: C7H8N2O4

Chemical Name: N,3,4,5-tetrahydroxybenzene-1-carboximidamide

Smiles: N=C(NO)C1=CC(O)=C(O)C(O)=C1

InChiKey: MSLJYSGFUMYUDX-UHFFFAOYSA-N

InChi: InChI=1S/C7H8N2O4/c8-7(9-13)3-1-4(10)6(12)5(11)2-3/h1-2,10-13H,(H2,8,9)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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