tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus]

P53 is a sequence-specific DNA-binding oligomeric protein that can activate transcription from promoters bearing p53-binding sites. Whereas the activation region of p53 has been identified within the amino terminus, the location of the specific DNA-binding domain has not been reported1. Tumor protein p53 binding protein (53BP1) has been identified in a yeast two hybrid screen as a protein that interacts with the central DNA-binding domain of p532. Similar to breast cancer susceptibility gene 13, 4 (BRCA1; 53BP1 enhances p53-dependent transcription5. Interestingly, the COOH terminus of 53BP1 contains tandem BRCA1 COOH terminus (BRCT) motifs. 53BP1 becomes hyperphosphorylated and rapidly relocates to the sites of DNA strand breaks in response to ionizing radiation. 53BP1 foci formation is reduced in ATM-deficient cells and can be inhibited by wortmannin in ATM wild-type cells. Moreover, radiation-induced hyperphosphorylation of 53BP1 is absent in cells treated with wortmannin, as well as in ATM-deficient cells. 53BP1 participates in DNA damage-signaling pathways and is regulated by ATM after ǃ-radiation6.

Product information

Molecular Weight: 1242.38

Formula: C57H87N13O18

Chemical Name: 4-{[5-amino-1-({3-carboxy-1-[(1-carboxy-2-methylpropyl)carbamoyl]propyl}carbamoyl)pentyl]carbamoyl}-4-[(1-{2-[2-(2-{2-[2-amino-3-(4-hydroxyphenyl)propanamido]-4-methylpentanamido}-3-(1H-imidazol-5-yl)propanamido)-3-methylbutanamido]-4-carboxybutanoyl}pyrrolidin-2-yl)formamido]butanoic acid

Smiles: CC(C)CC(NC(=O)C(N)CC1=CC=C(O)C=C1)C(=O)NC(CC1=CN=CN1)C(=O)NC(C(C)C)C(=O)NC(CCC(O)=O)C(=O)N1CCCC1C(=O)NC(CCC(O)=O)C(=O)NC(CCCCN)C(=O)NC(CCC(O)=O)C(=O)NC(C(C)C)C(O)=O

InChiKey: UXACOKSUEHOCCM-UHFFFAOYSA-N

InChi: InChI=1S/C57H87N13O18/c1-29(2)24-40(66-48(78)35(59)25-32-12-14-34(71)15-13-32)52(82)67-41(26-33-27-60-28-61-33)53(83)68-46(30(3)4)55(85)65-39(18-21-45(76)77)56(86)70-23-9-11-42(70)54(84)64-37(16-19-43(72)73)50(80)62-36(10-7-8-22-58)49(79)63-38(17-20-44(74)75)51(81)69-47(31(5)6)57(87)88/h12-15,27-31,35-42,46-47,71H,7-11,16-26,58-59H2,1-6H3,(H,60,61)(H,62,80)(H,63,79)(H,64,84)(H,65,85)(H,66,78)(H,67,82)(H,68,83)(H,69,81)(H,72,73)(H,74,75)(H,76,77)(H,87,88)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.