survivin (baculoviral IAP repeat-containing protein 5) (21-28)

Survivin (baculoviral inhibitor of apoptosis IAP repeat-containing protein-5) is a member of the IAP gene family, which has been implicated in both inhibition of apoptosis and mitosis regulation1. Survivin is one of the most uniformly up-regulated genes in tumor tissues compared with healthy tissues2. High survivin expression in the primary tumor is almost invariably associated with poor patient prognosis in many cancer types. Survivin relates to poor disease outcome in a variety of tumors, i.e., neuroblastoma3, colorectal cancer4, non-small-cell lung cancers5, B-cell lymphoma6, T-cell leukemia7, hepatocellular carcinoma, esophageal carcinoma, rectal cancer, glioma, bladder cancer, soft tissue sarcoma and astrocytic tumors. Survivin mRNA, as measured by quantitative RT-PCR in the primary tumor, has strong and independent prognostic value in human breast cancer. Survivin mRNA concentrations in the tumor can be used to classify breast cancer patients into different risk groups. 8 Cells that are unresponsive to apoptotic triggers will also be more resistant to cytotoxic treatments, as are cells that overexpress survivin9.

Product information

Molecular Weight: 1052.22

Formula: C54H73N11O11

Chemical Name: 2-[2-({1-[2-(2-{6-amino-2-[2-(2-amino-3-hydroxybutanamido)-3-phenylpropanamido]hexanamido}-3-carbamoylpropanamido)-3-(1H-indol-3-yl)propanoyl]pyrrolidin-2-yl}formamido)-3-phenylpropanamido]-4-methylpentanoic acid

Smiles: CC(C)CC(NC(=O)C(CC1C=CC=CC=1)NC(=O)C1CCCN1C(=O)C(CC1=CNC2C=CC=CC1=2)NC(=O)C(CC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CC1C=CC=CC=1)NC(=O)C(N)C(C)O)C(O)=O

InChiKey: DTXTWVPNZUUFFC-UHFFFAOYSA-N

InChi: InChI=1S/C54H73N11O11/c1-31(2)25-43(54(75)76)64-49(70)39(26-33-15-6-4-7-16-33)61-51(72)44-22-14-24-65(44)53(74)42(28-35-30-58-37-20-11-10-19-36(35)37)63-50(71)41(29-45(56)67)60-47(68)38(21-12-13-23-55)59-48(69)40(27-34-17-8-5-9-18-34)62-52(73)46(57)32(3)66/h4-11,15-20,30-32,38-44,46,58,66H,12-14,21-29,55,57H2,1-3H3,(H2,56,67)(H,59,69)(H,60,68)(H,61,72)(H,62,73)(H,63,71)(H,64,70)(H,75,76)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.