surface antigen (208-215) [Hepatitis B Virus]

The nucleocapsid of hepatitis B virus is covered by an envelope of HBV surface antigen (HBsAg), which has the common, group-specific determinant a. The four major subtypes of HBsAg, adw, adr, ayw and ayr, are generated, and they have been proposed to represent the phenotypic expression of the four major genotypes of HBV1. HBsAg subtypes show distinct geographical distributions2 and may provide historical information on the migration of ancestors carrying HBV of a particular subtype3. The HBsAg, localized on the surface of the infectious Dane particle is considered to be the antigen responsible for conferring immunity to infection with hepatitis B4. A larger amount is found on filaments of 20-nm diameter and variable length. By far the most HBsAg is present on small, noninfectious, 20-nm particles5. Refences: 1.Le Bouvier, G. L., Mccollum, R. W., Hierholzer, W. J., Irwin, G. R., Krugman, S. & Giles, J. P. (1972). Subtypes of Australia antigen and hepatitis-B virus. 222, 928-930 2.Courouce-Pauty, A. M., Plancon, A. & Soulier, J. P. (1983). Distribution of HBsAg subtypes in the world. 44, 197-211. 3.Yamashita, Y., Kurashina, S., Miyakawa, Y. & Mayumi, M. (1975). South-to-north gradient in distribution of the r determinant of hepatitis B surface antigen in Japan. 131, 567-569. 4.A. M. Moriarty, B. H. Hoyer Expression of the hepatitis B virus surface antigen gene in cell culture by using a simian virus 40 vector. . 78: 2606-2610(1981).

Product information

Molecular Weight: 899.13

Formula: C46H74N8O10

Chemical Name: 2-{[1-(2-{2-[(1-{2-[2-(2-amino-3-methylpentanamido)-4-methylpentanamido]-3-hydroxypropanoyl}pyrrolidin-2-yl)formamido]-3-phenylpropanamido}-4-methylpentanoyl)pyrrolidin-2-yl]formamido}-4-methylpentanoic acid

Smiles: CC(CC)C(N)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)N1CCCC1C(=O)NC(CC1C=CC=CC=1)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(O)=O

InChiKey: YOHSEFYXDZHYNW-UHFFFAOYSA-N

InChi: InChI=1S/C46H74N8O10/c1-9-29(8)38(47)43(60)49-31(21-26(2)3)39(56)52-35(25-55)45(62)54-20-14-17-36(54)41(58)48-32(24-30-15-11-10-12-16-30)40(57)50-33(22-27(4)5)44(61)53-19-13-18-37(53)42(59)51-34(46(63)64)23-28(6)7/h10-12,15-16,26-29,31-38,55H,9,13-14,17-25,47H2,1-8H3,(H,48,58)(H,49,60)(H,50,57)(H,51,59)(H,52,56)(H,63,64)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.