Methyltetrazine-PEG5-NHS ester


Catalog No. Size PriceQuantity
M25128-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 1802907-92-1

Molecular Weight: 533.53

Formula: C24H31N5O9

Chemical Name: 2,5-dioxopyrrolidin-1-yl 1-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]-3,6,9,12-tetraoxapentadecan-15-oate

Smiles: CC1N=NC(=NN=1)C1C=CC(=CC=1)OCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O

InChiKey: SWSUSQWZOPGVKP-UHFFFAOYSA-N

InChi: InChI=1S/C24H31N5O9/c1-18-25-27-24(28-26-18)19-2-4-20(5-3-19)37-17-16-36-15-14-35-13-12-34-11-10-33-9-8-23(32)38-29-21(30)6-7-22(29)31/h2-5H,6-17H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.

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