Description
BAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe with IC50s of 21 and 24 nM for human and rat GnRH-R, respectively.
Product information
CAS Number: 1631164-24-3
Molecular Weight: 672.11
Formula: C29H26ClF4N3O5S2
Chemical Name: (2S)-N-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}-2-cyclopropyl-1-(4-fluorobenzenesulfonyl)-1',1'-dioxo-1,2-dihydrospiro[indole-3,4'-[1λ⁶]thiane]-5-carboxamide
Smiles: O=C(NCC1=NC=C(C=C1Cl)C(F)(F)F)C1=CC2=C(C=C1)N([C@@H](C1CC1)C12CCS(=O)(=O)CC1)S(=O)(=O)C1C=CC(F)=CC=1
InChiKey: PZGSYNNVPNLHQG-SANMLTNESA-N
InChi: InChI=1S/C29H26ClF4N3O5S2/c30-23-14-19(29(32,33)34)15-35-24(23)16-36-27(38)18-3-8-25-22(13-18)28(9-11-43(39,40)12-10-28)26(17-1-2-17)37(25)44(41,42)21-6-4-20(31)5-7-21/h3-8,13-15,17,26H,1-2,9-12,16H2,(H,36,38)/t26-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
BAY-784 (0.5, 3, 10, and 30 mg/kg; 24 hours; single p.o.) suppresses the plasma luteinizing hormone (LH) concentration in ovariectomized (OVX) rats in a dose-dependent manner.
Products are for research use only. Not for human use.
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