{"product_id":"m34680","title":"TM5441sodium","description":"\u003cp style=\"padding-left:1em;\"\u003eTM-5441, also known as EBP 883 and BMS-790052, is a potent plasminogen activator inhibitor-1 (PAI-1). TM-5441 inhibits several tumor cell lines with IC50 values between 9.7 and 60.3 μM. TM5441 protects against high-fat diet-induced obesity and adipocyte injury in mice.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eProduct information\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 2319722-53-5\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 450.80\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eFormula:\u003c\/strong\u003e C21H16ClN2NaO6\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSynonym:\u003c\/strong\u003e\u003c\/p\u003e\u003cp style=\"padding-left:1em;\"\u003eTM5441sodiumTM-5441\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eRelated CAS Number:\u003c\/strong\u003e\u003c\/p\u003e\u003cp style=\"padding-left:1em;\"\u003e1190221-43-2\u003c\/p\u003e\u003cp style=\"padding-left:1em;\"\u003e2319722-53-5\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eChemical Name:\u003c\/strong\u003e 5-Chloro-2-[[2-[2-[[3-(3-furanyl)phenyl]amino]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eSmiles:\u003c\/strong\u003e [Na+].[O-]C(=O)C1=CC(Cl)=CC=C1NC(=O)COCC(=O)NC1=CC(=CC=C1)C1=COC=C1\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eInChiKey:\u003c\/strong\u003e RDKPAESSEMYFJL-UHFFFAOYSA-M\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eInChi:\u003c\/strong\u003e InChI=1S\/C21H17ClN2O6.Na\/c22-15-4-5-18(17(9-15)21(27)28)24-20(26)12-30-11-19(25)23-16-3-1-2-13(8-16)14-6-7-29-10-14;\/h1-10H,11-12H2,(H,23,25)(H,24,26)(H,27,28);\/q;+1\/p-1\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTechnical Data\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAppearance:\u003c\/strong\u003e Solid Power\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (or refer to the Certificate of Analysis)\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e To be determined\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eShipping Condition:\u003c\/strong\u003e Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eStorage Condition:\u003c\/strong\u003e Dry, dark and -20 \u003csup\u003eo\u003c\/sup\u003eC for 1 year or refer to the Certificate of Analysis.\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eShelf Life:\u003c\/strong\u003e ≥12 months if stored properly.\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eStock Solution Storage:\u003c\/strong\u003e 0 - 4 \u003csup\u003eo\u003c\/sup\u003eC for 1 month or refer to the Certificate of Analysis.\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eDrug Formulation:\u003c\/strong\u003e To be determined\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eHS Tariff Code:\u003c\/strong\u003e 382200\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\u003col style=\"padding-left:1em;\"\u003e\n\u003cli\u003eMedipally A, Xiao M, Biederman L, Dasgupta A, Satoskar AA, Parikh S, Ivanov I, Mikhalina G, Brodsky SV. Role of plasminogen activated inhibitor-1 in the pathogenesis of anticoagulant related nephropathy. Front Nephrol. 2024 Jun 28;4:1406655. doi: 10.3389\/fneph.2024.1406655. PMID: 39006160; PMCID: PMC11239567.\u003c\/li\u003e\n\u003cli\u003eCipolla MJ, Hunt RD, Liebeskind DS, Tremble SM. The impact of collateral therapeutics on stroke hemodynamics in normotensive and hypertensive rats: a step toward translation. Front Neurol. 2024 Mar 21;15:1373445. doi: 10.3389\/fneur.2024.1373445. PMID: 38585360; PMCID: PMC10996366.\u003c\/li\u003e\n\u003cli\u003eTanaka K, Harada H, Kamuro H, Sakai H, Yamamoto A, Tomimatsu M, Ikeda A, Chosokabe R, Tanaka S, Okada Y, Fujio Y, Obana M. Arid5a\/IL-6\/PAI-1 Signaling Is Involved in the Pathogenesis of Lipopolysaccharide-Induced Kidney Injury. Biol Pharm Bull. 2023;46(12):1753-1760. doi: 10.1248\/bpb.b23-00482. PMID: 38044094.\u003c\/li\u003e\n\u003cli\u003ePalakurti R, Biswas N, Roy S, Gnyawali SC, Sinha M, Singh K, Ghatak S, Sen CK, Khanna S. Inducible miR-1224 silences cerebrovascular Serpine1 and restores blood flow to the stroke-affected site of the brain. Mol Ther Nucleic Acids. 2023 Jan 2;31:276-292. doi: 10.1016\/j.omtn.2022.12.019. PMID: 36726407; PMCID: PMC9868883.\u003c\/li\u003e\n\u003cli\u003eShin E, Kang H, Lee H, Lee S, Jeon J, Seong K, Youn H, Youn B. Exosomal Plasminogen Activator Inhibitor-1 Induces Ionizing Radiation-Adaptive Glioblastoma Cachexia. Cells. 2022 Oct 1;11(19):3102. doi: 10.3390\/cells11193102. PMID: 36231065; PMCID: PMC9564109.\u003c\/li\u003e\n\u003c\/ol\u003e\u003cp\u003e\u003cstrong\u003eProducts are for research use only. Not for human use.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Xcess Biosciences","offers":[{"title":"M34680-C \/ Contact sales@xcessbio.com for quotation","offer_id":42987633082507,"sku":null,"price":100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0389\/1897\/9723\/files\/M34680_1735794083.gif?v=1735798794","url":"https:\/\/www.xcessbio.com\/products\/m34680","provider":"Xcess Biosciences","version":"1.0","type":"link"}