{"product_id":"m34681","title":"MIF098","description":"\u003cp style=\"padding-left:1em;\"\u003eMIF098 is a macrophage migration inhibitory factor (MIF) antagonist.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eProduct information\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 1208448-95-6\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 255.27\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eFormula:\u003c\/strong\u003e C15H13NO3\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSynonym:\u003c\/strong\u003e\u003c\/p\u003e\u003cp style=\"padding-left:1em;\"\u003eMIF098\u003c\/p\u003e\u003cp style=\"padding-left:1em;\"\u003eMIF-098\u003c\/p\u003e\u003cp style=\"padding-left:1em;\"\u003eMIF 098\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eChemical Name:\u003c\/strong\u003e 3-(3-hydroxybenzyl)-5-methylbenzo[d]oxazol-2(3H)-one\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eSmiles:\u003c\/strong\u003e CC1=CC2=C(C=C1)OC(=O)N2CC1=CC(O)=CC=C1\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eInChiKey:\u003c\/strong\u003e JJXKGUBHEQGADG-UHFFFAOYSA-N\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eInChi:\u003c\/strong\u003e InChI=1S\/C15H13NO3\/c1-10-5-6-14-13(7-10)16(15(18)19-14)9-11-3-2-4-12(17)8-11\/h2-8,17H,9H2,1H3\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTechnical Data\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAppearance:\u003c\/strong\u003e Solid Power\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (or refer to the Certificate of Analysis)\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e To be determined\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eShipping Condition:\u003c\/strong\u003e Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eStorage Condition:\u003c\/strong\u003e Dry, dark and -20 \u003csup\u003eo\u003c\/sup\u003eC for 1 year or refer to the Certificate of Analysis.\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eShelf Life:\u003c\/strong\u003e ≥12 months if stored properly.\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eStock Solution Storage:\u003c\/strong\u003e 0 - 4 \u003csup\u003eo\u003c\/sup\u003eC for 1 month or refer to the Certificate of Analysis.\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eDrug Formulation:\u003c\/strong\u003e To be determined\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eHS Tariff Code:\u003c\/strong\u003e 382200\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\u003col style=\"padding-left:1em;\"\u003e\n\u003cli\u003eHuang H, Chen D, Pu J, Yuan A, Fu Q, Li J, Leng L, Bucala R, Ye S, Lu L. The\nsmall molecule macrophage migration inhibitory factor antagonist MIF098,\ninhibits pulmonary hypertension associated with murine SLE. Int Immunopharmacol.\n2019 Nov;76:105874. doi: 10.1016\/j.intimp.2019.105874. Epub 2019 Sep 6. PMID:\n31499270.\u003c\/li\u003e\n\u003cli\u003eHarrison DE, Strong R, Reifsnyder P, Kumar N, Fernandez E, Flurkey K, Javors\nMA, Lopez-Cruzan M, Macchiarini F, Nelson JF, Markewych A, Bitto A, Sindler AL,\nCortopassi G, Kavanagh K, Leng L, Bucala R, Rosenthal N, Salmon A, Stearns TM,\nBogue M, Miller RA. 17-a-estradiol late in life extends lifespan in aging UM-\nHET3 male mice; nicotinamide riboside and three other drugs do not affect\nlifespan in either sex. Aging Cell. 2021 May;20(5):e13328. doi:\n10.1111\/acel.13328. Epub 2021 Mar 31. Erratum in: Aging Cell. 2022\nNov;21(11):e13672. doi: 10.1111\/acel.13672. PMID: 33788371; PMCID: PMC8135004.\u003c\/li\u003e\n\u003cli\u003eShin MS, Kang Y, Wahl ER, Park HJ, Lazova R, Leng L, Mamula M, Krishnaswamy\nS, Bucala R, Kang I. Macrophage Migration Inhibitory Factor Regulates U1 Small\nNuclear RNP Immune Complex-Mediated Activation of the NLRP3 Inflammasome.\nArthritis Rheumatol. 2019 Jan;71(1):109-120. doi: 10.1002\/art.40672. Epub 2018\nDec 4. PMID: 30009530; PMCID: PMC6310104.\u003c\/li\u003e\n\u003cli\u003ePoulsen KL, McMullen MR, Huang E, Kibler CD, Sheehan MM, Leng L, Bucala R,\nNagy LE. Novel Role of Macrophage Migration Inhibitory Factor in Upstream\nControl of the Unfolded Protein Response After Ethanol Feeding in Mice. Alcohol\nClin Exp Res. 2019 Jul;43(7):1439-1451. doi: 10.1111\/acer.14065. Epub 2019 May\n14. PMID: 31009094; PMCID: PMC6602811.\u003c\/li\u003e\n\u003cli\u003eMa F, Hunt DE, Leng L, Bucala R, Meyer-Siegler KL, Vera PL. Protease\nactivated-receptor 4 activation as a model of persistent bladder pain: Essential\nrole of macrophage migration inhibitory factor and high mobility group box 1.\nInt J Urol. 2018 Oct;25(10):887-893. doi: 10.1111\/iju.13778. Epub 2018 Aug 15.\nPMID: 30112848; PMCID: PMC6436093.\u003c\/li\u003e\n\u003c\/ol\u003e\u003cp\u003e\u003cstrong\u003eProducts are for research use only. Not for human use.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Xcess Biosciences","offers":[{"title":"M34681-C \/ Contact sales@xcessbio.com for quotation","offer_id":42987633148043,"sku":null,"price":100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0389\/1897\/9723\/files\/M34681_1735794086.gif?v=1735798806","url":"https:\/\/www.xcessbio.com\/products\/m34681","provider":"Xcess Biosciences","version":"1.0","type":"link"}