AS8351, KDM5B Inhibitor

Catalog No. size PriceQuantity
M60330-2S 2 mg solid $109
M60330-10S 10mg solid $447


AS8351 is a potent iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B) by competing with a-ketoglutarate. KDM5B a histone H3K4 demethylase involved in regulation of cell proliferation and stem cell self-renewal and differentiation. It can induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR99021, A83-01, BIX01294, SC1, Y-27632, OAC2, SU16f and JNJ10198409.

Product information

CAS Number: 796-42-9

Molecular Weight: 291.30

Formula: C17H13N3O2

Chemical Name: 2-Hydroxy-1-naphthaldehyde isonicotinoylhydrazone

Smiles: OC1=CC=C2C=CC=CC2=C1C=NNC(=O)C1C=CN=CC=1


InChi: InChI=1S/C17H13N3O2/c21-16-6-5-12-3-1-2-4-14(12)15(16)11-19-20-17(22)13-7-9-18-10-8-13/h1-11,21H,(H,20,22)/b19-11+

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

AS8351 was used at 1-10 µM in vitro and cellular assays.


  1. Cao N, et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. (2016) Science. 352(6290):1216-20.

Products are for research use only. Not for human use.


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