Description
Product Information
| Molecular Weight: | 291.31 |
| Formula: | C17H13N3O2 |
| Purity: | ≥98% |
| CAS#: | 796-42-9 |
| Solubility: | DMSO up to 100 mM |
| Chemical Name: | 2-Hydroxy-1-naphthaldehyde isonicotinoylhydrazone |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
AS8351 is a potent iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B) by competing with a-ketoglutarate. KDM5B a histone H3K4 demethylase involved in regulation of cell proliferation and stem cell self-renewal and differentiation. It can induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR99021, A83-01, BIX01294, SC1, Y-27632, OAC2, SU16f and JNJ10198409.
How to Use:
In vitro: AS8351 was used at 1-10 µM in vitro and cellular assays.
In vivo: n/a
Reference:
- 1. Cao N, et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. (2016) Science. 352(6290):1216-20.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.