Catalog No. size PriceQuantity
M6454-2 2mg solid $106
M6454-10 10mg solid $452



Product Information

Vacquinol-1, also known as NSC 13316, is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells. Vacquinol-1 has beneficial effects on a glioblastoma multiforme mouse model by oral administration. In glioblastoma cells, Vacquinol-1 targets macropinocytosis, a cellular process that will not lead to cell death in normal cells.


Chemical Formula: C21H21ClN2O


Exact Mass: 352.1342


Molecular Weight: 352.862


Elemental Analysis: C, 71.48; H, 6.00; Cl, 10.05; N, 7.94; O, 4.53




NSC 13316





Chemical Name:



InChi Key:



InChi Code: InChI=1S/C21H21ClN2O/c22-15-10-8-14(9-11-15)20-13-17(16-5-1-2-6-18(16)24-20)21(25)19-7-3-4-12-23-19/h1-2,5-6,8-11,13,19,21,23,25H,3-4,7,12H2


Smiles Code:




Technical Data:


Appearance: White to beige solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001





  1. Aki T, Funakoshi T, Uemura K. Regulated necrosis and its implications in toxicology. Toxicology. 2015 Jul 3;333:118-26. doi: 10.1016/j.tox.2015.04.003. Epub 2015 Apr 9. Review. PubMed PMID: 25865964.


  1. Shi Y, Lim SK, Parada LF. The soft underbelly of tumor cells. Cell Res. 2014 Aug;24(8):910-1. doi: 10.1038/cr.2014.72. Epub 2014 May 30. PubMed PMID: 24874955; PubMed Central PMCID: PMC4123293.


  1. Gilbertson RJ. Driving glioblastoma to drink. Cell. 2014 Apr 10;157(2):289-90. doi: 10.1016/j.cell.2014.03.034. PubMed PMID: 24725398.


  1. Kitambi SS, Toledo EM, Usoskin D, Wee S, Harisankar A, Svensson R, Sigmundsson K, Kalderén C, Niklasson M, Kundu S, Aranda S, Westermark B, Uhrbom L, Andäng M, Damberg P, Nelander S, Arenas E, Artursson P, Walfridsson J, Forsberg Nilsson K, Hammarström LG, Ernfors P. Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule. Cell. 2014 Apr 10;157(2):313-28. doi: 10.1016/j.cell.2014.02.021. Epub 2014 Mar 20. PubMed PMID: 24656405.


Products are for research use only. Not for human use.


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