Catalog No. size PriceQuantity
M6454-2 2mg solid $106
M6454-10 10mg solid $452


Vacquinol-1, also known as NSC 13316, is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells. Vacquinol-1 has beneficial effects on a glioblastoma multiforme mouse model by oral administration. In glioblastoma cells, Vacquinol-1 targets macropinocytosis, a cellular process that will not lead to cell death in normal cells.

Product information

CAS Number: 5428-80-8

Molecular Weight: 352.86

Formula: C21H21ClN2O



NSC 13316



Chemical Name: (2-(4-chlorophenyl)quinolin-4-yl)(piperidin-2-yl)methanol

Smiles: OC(C1CCCCN1)C1=CC(=NC2=CC=CC=C12)C1=CC=C(Cl)C=C1


InChi: InChI=1S/C21H21ClN2O/c22-15-10-8-14(9-11-15)20-13-17(16-5-1-2-6-18(16)24-20)21(25)19-7-3-4-12-23-19/h1-2,5-6,8-11,13,19,21,23,25H,3-4,7,12H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO, not in water

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200


  1. Aki T, Funakoshi T, Uemura K. Regulated necrosis and its implications in toxicology. Toxicology. 2015 Jul 3;333:118-26. doi: 10.1016/j.tox.2015.04.003. Epub 2015 Apr 9. Review. PubMed PMID: 25865964.
  2. Shi Y, Lim SK, Parada LF. The soft underbelly of tumor cells. Cell Res. 2014 Aug;24(8):910-1. doi: 10.1038/cr.2014.72. Epub 2014 May 30. PubMed PMID: 24874955; PubMed Central PMCID: PMC4123293.
  3. Gilbertson RJ. Driving glioblastoma to drink. Cell. 2014 Apr 10;157(2):289-90. doi: 10.1016/j.cell.2014.03.034. PubMed PMID: 24725398.

Products are for research use only. Not for human use.

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