B-Raf IN 1

Catalog No. size PriceQuantity
M6584-2 2mg solid $128
M6584-10 10mg solid $516



Product Information

B-Raf IN 1 is a potent b-Raf inhibitor. B-Raf IN 1 has CAS#950736-05-7. The last 5 digit CAS# was used in its code name for easy communication.


Chemical Formula: C29H24F3N5O


Exact Mass: 515.193


Molecular Weight: 515.5402


Elemental Analysis: C, 67.56; H, 4.69; F, 11.06; N, 13.58; O, 3.10




B-Raf-IN 1;




MDK 36057


Chemical Name: N-[3-[3-[4-[(Dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)benzamide


InChi Key:



InChi Code:



Smiles Code:




Technical Data:


Appearance: Yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


In Vitro

B-Raf IN 1 (Compound 10n) inhibits WM 266-4 and HT29 cells with IC50s of 0.92 and 0.78 μM, respectively.





  1. Berger DM, et al. Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23.


Products are for research use only. Not for human use.

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