B-Raf IN 1


Catalog No. size PriceQuantity
M6584-2 2mg solid $128
M6584-10 10mg solid $516

Description

Cas:950736-05-7

Product Information

B-Raf IN 1 is a potent b-Raf inhibitor. B-Raf IN 1 has CAS#950736-05-7. The last 5 digit CAS# was used in its code name for easy communication.

 

Chemical Formula: C29H24F3N5O

 

Exact Mass: 515.193

 

Molecular Weight: 515.5402

 

Elemental Analysis: C, 67.56; H, 4.69; F, 11.06; N, 13.58; O, 3.10

 

Synonym: 

 

B-Raf-IN 1;

B-Raf-IN1;

MDK36057;

MDK-36057;

MDK 36057

 

Chemical Name: N-[3-[3-[4-[(Dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)benzamide

 

InChi Key:

AIWJVLQNYNCDSL-UHFFFAOYSA-N

 

InChi Code:

InChI=1S/C29H24F3N5O/c1-36(2)18-19-9-11-20(12-10-19)25-17-34-37-26(13-14-33-27(25)37)21-5-4-8-24(16-21)35-28(38)22-6-3-7-23(15-22)29(30,31)32/h3-17H,18H2,1-2H3,(H,35,38)

 

Smiles Code:

O=C(NC1=CC=CC(C2=CC=NC3=C(C4=CC=C(CN(C)C)C=C4)C=NN23)=C1)C5=CC=CC(C(F)(F)F)=C5

 

 

Technical Data:

 

Appearance: Yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vitro

B-Raf IN 1 (Compound 10n) inhibits WM 266-4 and HT29 cells with IC50s of 0.92 and 0.78 μM, respectively.

 

 

References

 

  1. Berger DM, et al. Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23.

 

Products are for research use only. Not for human use.

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