Remodelin


Catalog No. size PriceQuantity
M6677-2 2mg solid $100
M6677-10 10mg solid $294

Description

Cas:949912-58-7

Product Information

Remodelin is an inhibitor of N-acetyltransferase 10 (NAT10), which acetylates both histones and microtubules. Remodelin improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria.

 

Chemical Formula: C15H14N4S

 

Exact Mass: 282.0939

 

Molecular Weight: 282.36 

 

Elemental Analysis: C, 63.81; H, 5.00; N, 19.84; S, 11.35

 

Synonym: 

 

Remodelin

949912-58-7

CHEMBL399572

4-(2-(2-cyclopentylidenehydrazinyl)thiazol-4-yl)benzonitrile

4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile

GTPL8102

SCHEMBL17144586

BCP11087

EX-A1315

BDBM50326653

ZINC28951699

AKOS025293490

CS-3458

NCGC00384186-14

HY-16706

Q27088531

4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile

4-[2-(N''-cyclopentylidene-hydrazino)-thiazol-4-yl]-benzonitrile

 

Chemical Name:

4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile

 

InChi Key:

XAEJIFARBQJLML-UHFFFAOYSA-N

 

InChi Code:  InChI=1S/C15H14N4S/c16-9-11-5-7-12(8-6-11)14-10-20-15(17-14)19-18-13-3-1-2-4-13/h5-8,10H,1-4H2,(H,17,19)

 

Smiles Code:

N#CC1=CC=C(C2=CSC(N/N=C3CCCC\3)=N2)C=C1

 

 

Technical Data:

 

Appearance: A crystalline solid

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life:>23 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

 

References

 

  1. Larrieu, D., Britton, S., Demir, M., et al. Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science 344(6183), 527-532 (2014).

 

  1. Chimenti, F., Bizzarri, B., Maccioni, E., et al. Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp. Bioorganic & Medicinal Chemistry Letters 17(16), 4635-4640 (2007).

 

Products are for research use only. Not for human use.

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