Catalog No. size PriceQuantity
M6705-2 2mg solid $103
M6705-10 10mg solid $396


TA-01 is an inducer of cardiomyocyte differentiation from human embryonic stem cells following mesoderm induction.

Product information

CAS Number: 1784751-18-3

Molecular Weight: 351.32

Formula: C20H12F3N3



TA 01


Chemical Name: 4-(2-(2,6-difluorophenyl)-4-(2-fluorophenyl)-1H-imidazol-5-yl)pyridine

Smiles: FC1C=CC=C(F)C=1C1NC(=C(N=1)C1=CC=CC=C1F)C1C=CN=CC=1


InChi: InChI=1S/C20H12F3N3/c21-14-5-2-1-4-13(14)19-18(12-8-10-24-11-9-12)25-20(26-19)17-15(22)6-3-7-16(17)23/h1-11H,(H,25,26)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively. TA-01 (5 μM) is not cytotoxic, completely inhibits cardiogenesis, but induces cardiogenesis at lower concentration.


  1. Laco F, et al. Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling. J Mol Cell Cardiol. 2015 Mar;80:56-70.

Products are for research use only. Not for human use.

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