EMT inhibitor-1

Catalog No. size PriceQuantity
M6935-2 2mg solid $201
M6935-10 10mg solid $806



Product Information:

EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.

IC50 & Target: Hippo, TGF-β, Wnt


Molecular Weight: 319.21


Formula: C₁₂H₁₂Cl₂N₂O₂S






Room temperature in continental US; may vary elsewhere.



Powder    -20°C 3 years

4°C 2 years

In solvent -80°C 6 months

-20°C 1 month


In Vitro:

EMT inhibitor-1 (C19) (0-10μM; 24 hours) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities, inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro.


In Vivo:

EMT inhibitor-1 (C19) (intraperitoneal injection; 5-20 mg/kg) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex.C19 is dissolved in the vehicle solution (100 μL of DMEM containing 5% dimethyl sulfoxide).





  1. Basu D, et al. Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-β, and Wnt signaling pathways. Mol Cancer Ther. 2014 Jun;13(6):1457-67.


Products are for research use only. Not for human use.



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