iHAP1 (Compound 14b in literature 1) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. CUN25391 inhibits tubulin polymerization with an IC50 of 0.87 μM. CUN25391 has CAS#105925-39-1, no formal name. For the convenience of scientific communication, we named it as CUN25391(combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature
Chemical Formula: C20H14ClNO2S
Exact Mass: 367.0434
Molecular Weight: 367.847
Elemental Analysis: C, 65.30; H, 3.84; Cl, 9.64; N, 3.81; O, 8.70; S, 8.72
Tubulin inhibitor 6
InChi Code: InChI=1S/C20H14ClNO2S/c1-24-15-9-6-13(7-10-15)20(23)22-16-4-2-3-5-18(16)25-19-11-8-14(21)12-17(19)22/h2-12H,1H3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
Tubulin inhibitor 6 displays submicromolar antiproliferative activity.
Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54(12):4247-63.
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