TBK1 control PROTAC 4


Catalog No. size PriceQuantity
M7150-2 2mg solid $121
M7150-10 10mg solid $482

Description

TBK1 control PROTAC 4 is a negative control for TBK1 PROTAC 3i. It binds TBK1 with high affinity, but exhibits no significant degradation of TBK1.

Product information

CAS Number: 2052306-31-5

Molecular Weight: 1093.18

Formula: C53H74BrN9O9S

Synonym:

TBK1controlPROTAC4

TBK1control PROTAC 4

Chemical Name: (2S,4S)-1-((S)-18-(4-((5-bromo-4-((3-(N-methylcyclobutanecarboxamido)propyl)amino)pyrimidin-2-yl)amino)phenoxy)-2-(tert-butyl)-4-oxo-6,10,15-trioxa-3-azaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Smiles: CN(CCCNC1=NC(NC2C=CC(=CC=2)OCCCOCCCCOCCCOCC(=O)N[C@H](C(=O)N2C[C@@H](O)C[C@H]2C(=O)NCC2C=CC(=CC=2)C2SC=NC=2C)C(C)(C)C)=NC=C1Br)C(=O)C1CCC1

InChiKey: QMGHHBHPDDAGGO-JTTRWUFTSA-N

InChi: InChI=1S/C53H74BrN9O9S/c1-36-46(73-35-58-36)38-16-14-37(15-17-38)31-56-49(66)44-30-41(64)33-63(44)51(68)47(53(2,3)4)60-45(65)34-71-28-10-26-69-24-6-7-25-70-27-11-29-72-42-20-18-40(19-21-42)59-52-57-32-43(54)48(61-52)55-22-9-23-62(5)50(67)39-12-8-13-39/h14-21,32,35,39,41,44,47,64H,6-13,22-31,33-34H2,1-5H3,(H,56,66)(H,60,65)(H2,55,57,59,61)/t41-,44-,47+/m0/s1

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

References:

  1. Crew et al (2018) Identification and characterization of Von Hippel-Lindau-recruiting proteolysis targeting chimeras (PROTACs) of TANK-binding kinase 1. J.Med.Chem. 61 583 PMID: 28692295

Products are for research use only. Not for human use.

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