Metarrestin (ML246)

Metarrestin (ML246) is an orally active and specific perinucleolar compartment (PNC) inhibitor that disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription. Metarrestin blocks metastatic development and extends survival in mouse cancer models.

Product information

CAS Number: 1443414-10-5

Molecular Weight: 474.60

Formula: C31H30N4O

Chemical Name: Trans-4-(7-benzyl-4-imino-5,6-diphenyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-3-yl) cyclohexanol

Smiles: N=C1C2=C(N=CN1[C@@H]1CC[C@@H](O)CC1)N(CC1C=CC=CC=1)C(=C2C1C=CC=CC=1)C1C=CC=CC=1

InChiKey: WSMXAUJFLWRPNT-DIVCQZSQSA-N

InChi: InChI=1S/C31H30N4O/c32-30-28-27(23-12-6-2-7-13-23)29(24-14-8-3-9-15-24)34(20-22-10-4-1-5-11-22)31(28)33-21-35(30)25-16-18-26(36)19-17-25/h1-15,21,25-26,32,36H,16-20H2/t25-,26-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 21 mg/mL(44.24 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Kevin J Frankowski, et al. Sci Transl Med. 2018 May 16;10(441):eaap8307.

Products are for research use only. Not for human use.