Description
NVP-QAV-680 is a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases. A highly selective compound, it has low nM functional potency for inhibition of CRTh2 driven human eosinophil and Th2 lymphocyte activation in vitro.
Product information
CAS Number: 872365-16-7
Molecular Weight: 358.41
Formula: C18H18N2O4S
Synonym:
QAV-690 free acid
NVP-QAV-680
Chemical Name: 2-{1-[(4-methanesulfonylphenyl)methyl]-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl}acetic acid
Smiles: CC1=C(CC(O)=O)C2=CC=CN=C2N1CC1C=CC(=CC=1)S(C)(=O)=O
InChiKey: YOPFAMROKXHVCQ-UHFFFAOYSA-N
InChi: InChI=1S/C18H18N2O4S/c1-12-16(10-17(21)22)15-4-3-9-19-18(15)20(12)11-13-5-7-14(8-6-13)25(2,23)24/h3-9H,10-11H2,1-2H3,(H,21,22)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Sandham DA, Arnold N, Aschauer H, Bala K, Barker L, Brown L, Brown Z, Budd D, Cox B, Docx C, Dubois G, Duggan N, England K, Everatt B, Furegati M, Hall E, Kalthoff F, King A, Leblanc CJ, Manini J, Meingassner J, Profit R, Schmidt A, Simmons J, Sohal B, Stringer R, Thomas M, Turner KL, Walker C, Watson SJ, Westwick J, Willis J, Williams G, Wilson C. Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases. Bioorg Med Chem. 2013 Nov 1;21(21):6582-91.
Products are for research use only. Not for human use.
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