{"product_id":"m9220","title":"RJR-2403 hemioxalate","description":"\u003cp style=\"padding-left:1em;\"\u003eMetanicotine, also known as RJR-2403 and TC-2403, is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype. Metanicotine has high affinity to rat brain cortex (Ki = 26 +\/- 3 nM). Metanicotine is comparable to nicotine in activating rat thalamic synaptosomes (EC50 = 732 +\/- 155 nM and Emax = 91 +\/- 8% for RJR-2403; EC50 = 591 +\/- 120 nM and Emax = 100 +\/- 25% for nicotine) . Chronic administration of RJR-2403 in combination with low-dose of 17beta-estradiol corrects passive avoidance learning in ovariectomized rats. RJR-2403 compensates the impairment of eyeblink conditioning produced by the noncompetitive NMDA-receptor antagonist MK-801.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eProduct information\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 207.25\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eFormula:\u003c\/strong\u003e C22H30N4O4\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSynonym:\u003c\/strong\u003e\u003c\/p\u003e\u003cp style=\"padding-left:1em;\"\u003eRivanicline\u003c\/p\u003e\u003cp style=\"padding-left:1em;\"\u003eRivanicline hemioxalate\u003c\/p\u003e\u003cp style=\"padding-left:1em;\"\u003eMetanicotine hemioxalate\u003c\/p\u003e\u003cp style=\"padding-left:1em;\"\u003eRJR 2403 hemioxalate\u003c\/p\u003e\u003cp style=\"padding-left:1em;\"\u003eRJR2403 hemioxalate\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eRelated CAS Number:\u003c\/strong\u003e\u003c\/p\u003e\u003cp style=\"padding-left:1em;\"\u003e15585-43-0 (free base)\u003c\/p\u003e\u003cp style=\"padding-left:1em;\"\u003e220662-95-3 (RJR-2403 oxalate(1:1))\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eChemical Name:\u003c\/strong\u003e (E)-N-methyl-4-(pyridin-3-yl)but-3-en-1-amine hemioxalate\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eSmiles:\u003c\/strong\u003e CNCC\/C=C\/C1=CN=CC=C1.CNCC\/C=C\/C1=CN=CC=C1.OC(=O)C(O)=O\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eInChiKey:\u003c\/strong\u003e VWROAWUIKILZJB-ITOWEXLMSA-N\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eInChi:\u003c\/strong\u003e InChI=1S\/2C10H14N2.C2H2O4\/c2*1-11-7-3-2-5-10-6-4-8-12-9-10;3-1(4)2(5)6\/h2*2,4-6,8-9,11H,3,7H2,1H3;(H,3,4)(H,5,6)\/b2*5-2+;\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTechnical Data\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAppearance:\u003c\/strong\u003e Solid Power\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (or refer to the Certificate of Analysis)\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e DMSO : 50 mg\/mL (241.28 mM; Need ultrasonic)\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eShipping Condition:\u003c\/strong\u003e Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eStorage Condition:\u003c\/strong\u003e Dry, dark and -20 \u003csup\u003eo\u003c\/sup\u003eC for 1 year or refer to the Certificate of Analysis.\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eShelf Life:\u003c\/strong\u003e ≥12 months if stored properly.\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eStock Solution Storage:\u003c\/strong\u003e 0 - 4 \u003csup\u003eo\u003c\/sup\u003eC for 1 month or refer to the Certificate of Analysis.\u003c\/p\u003e\u003cp style=\"text-indent:-1em;padding-left:1em;\"\u003e\u003cstrong\u003eDrug Formulation:\u003c\/strong\u003e To be determined\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eHS Tariff Code:\u003c\/strong\u003e 382200\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\u003col style=\"padding-left:1em;\"\u003e\n\u003cli\u003eBencherif M, et al. RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. J Pharmacol Exp Ther. 1996 Dec;279(3):1413-21.\u003c\/li\u003e\n\u003cli\u003eLippiello PM, et al. RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J Pharmacol Exp Ther. 1996 Dec;279(3):1422-9.\u003c\/li\u003e\n\u003cli\u003eDamaj MI, et al. Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist. J Pharmacol Exp Ther. 1999 Oct;291(1):390-8.\u003c\/li\u003e\n\u003c\/ol\u003e\u003cp\u003e\u003cstrong\u003eProducts are for research use only. Not for human use.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Xcess Biosciences","offers":[{"title":"M9220-2 \/ Contact sales@xcessbio.com for quotation","offer_id":39362919137419,"sku":"","price":100.0,"currency_code":"USD","in_stock":true},{"title":"M9220-10 \/ Contact sales@xcessbio.com for quotation","offer_id":39362919170187,"sku":"","price":100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0389\/1897\/9723\/products\/M9220_1621559858.gif?v=1627969748","url":"https:\/\/www.xcessbio.com\/products\/m9220","provider":"Xcess Biosciences","version":"1.0","type":"link"}