Description
RU 24969 hemisuccinate is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 hemisuccinate could decrease fluid consumption and increase forward locomotion.
Product information
CAS Number: 66611-27-6
Molecular Weight: 287.33
Formula: C32H38N4O6
Chemical Name: bis(5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole); butanedioic acid
Smiles: COC1C=C2C(=CNC2=CC=1)C1CCNCC=1.COC1C=C2C(=CNC2=CC=1)C1CCNCC=1.OC(=O)CCC(O)=O
InChiKey: BNYJLRQAWCQJOM-UHFFFAOYSA-N
InChi: InChI=1S/2C14H16N2O.C4H6O4/c2*1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10;5-3(6)1-2-4(7)8/h2*2-4,8-9,15-16H,5-7H2,1H3;1-2H2,(H,5,6)(H,7,8)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
RU 24969 (10 μM) reduces K+-stimulated release of [3H]-5-HT from ratfrontalcortex slices in vitro.
In Vivo:
RU 24969 (0.03-3.0 mg/kg; s.c.) dose-dependently decreases water consumption in water deprived rats. RU 24969 (0.3-3.0 mg/kg; s.c.) dose-dependently increases forward locomotion.
Products are for research use only. Not for human use.
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