Wee1 is a nuclear protein involved in the regulation of the G2/M checkpoint by negatively regulating entry into mitosis by catalyzing an inhibitory tyrosine phosphorylation of the Cdc2/cyclin B kinase complex.60 Activation of this complex (also known as maturation-promoting factor or MPF) is necessary to allow the entry into mitosis as it is involved in the direct modulation of the functions of number of proteins during cell division. Importantly, MPF only becomes active once DNA replication has been completed in order to permit a normal transition through the cell cycle. There are several levels of regulation of MPF activity, but Wee1 tyrosine kinase activity is a major regulatory component.
Xcess Biosciences Inc (XcessBio or Xbio) was founded in 2008 by scientists from academia and BioPharma industry with strong expertise in chemistry and biology. We are dedicated to develop high-quality products and deliver the best services for our customers.
Your orders will be processed within 24 hours if the requested items are available in stock. We do not ship out orders on Friday. Orders received on Friday will be shipped out in the morning of the following Monday.
We diligently develop high quality products and strive to earn your satisfaction. If for any reason you are not satisfied with your purchases, please follow our Return Policy for product return or exchange.
If you know of any technology, product, or service development opportunities in the fields related, we would be very interested in hearing from you. Please Contact Us.