Four NT receptors have been identified, two that are 7-transmembrane G protein-coupled receptors (NTR-1, NTR-2) and two primarily intracellular proteins related to yeast sorting receptors (NTR-3/sortilin, NTR-4/SorLA). NTR-1 displays the highest affinity (Kd, 0.1 nM) and seems to mediate NT effects on dopaminergic transmission, hot-plate latency, temperature regulation, and smooth muscle contractility. First described as a lower affinity receptor (Kd, 3 nM) with a differing specificity, NTR-2 has been implicated in the analgesic effects of NT. Although the role of NTR-3 is less clear, one possibility is that through binding and internalizing NT this receptor serves to regulate turnover of the peptide. Evidence supports the involvement of NTR-3 in the growth-promoting effects of NT and in NT-induced migration of brain microglial cells.
Xcess Biosciences Inc (XcessBio or Xbio) was founded in 2008 by scientists from academia and BioPharma industry with strong expertise in chemistry and biology. We are dedicated to develop high-quality products and deliver the best services for our customers.
Your orders will be processed within 24 hours if the requested items are available in stock. We do not ship out orders on Friday. Orders received on Friday will be shipped out in the morning of the following Monday.
We diligently develop high quality products and strive to earn your satisfaction. If for any reason you are not satisfied with your purchases, please follow our Return Policy for product return or exchange.
If you know of any technology, product, or service development opportunities in the fields related, we would be very interested in hearing from you. Please Contact Us.