Proline-rich tyrosine kinase 2 (Pyk2), also known as calcium-dependent tyrosine kinase (CADTK), is a nonreceptor tyrosine kinase belonging to the FAK (focal adhesion kinase) family. The Pyk2 contains several tyrosine residues, including the major autophosphorylation site (Y402), which acts as the binding site for the SH2 domains of Src and Fyn, and the putative binding site for the SH2 domain of Grb2. The Pyk2 is demonstrated to be involved in several cellular functions, such as cell adhesion, motility, proliferation, apoptosis and the cell cycle.
