Carboxypeptidases (CP) are zinc-containing exopeptidases that remove single amino acids from the carboxyl end of oligopeptides, many of which resulted from digestion of dietary proteins by pepsin, trypsin and chymotrypsin.
Carboxypeptidases are involved in a wide range of physiological processes, ranging from the digestion of food to the biosynthesis of peptides that function in cell-cell signaling. There are two major groups of carboxypeptidases; one uses serine as an active site residue and the other uses zinc in the active site Barrett et al (1998a), Barrett et al (1998b). The Serine and metallocarboxypeptidases do not share any amino acid sequence identity. The metallocarboxypeptidase family can be further divided into two subgroups based on amino acid sequence similarities. Each group has approximately 40–60% amino acid sequence identity with other members of the same group, but only 15–25% amino acid sequence identity with members of the other group. Each member of the metallocarboxypeptidase family can also be classified based on the substrate specificity: enzymes selective for C-terminal aromatic or aliphatic residues (CPA1, CPA2, CPA3, CPA5, and presumably CPA4 and CPA6—the activity of these two have not been reported); enzymes selective for C-terminal basic residues (CPB1, CPB2, CPD, CPE, CPM, CPN, and CPZ); enzymes presumably selective for C-terminal acid residues (CPO—the activity of this protein has not been reported); and carboxypeptidase-like proteins that lack one or more of the critical active site residues and that are not active as carboxypeptidases (AEBP1, CPX1, and CPX2).
Xcess Biosciences Inc (XcessBio or Xbio) was founded in 2008 by scientists from academia and BioPharma industry with strong expertise in chemistry and biology. We are dedicated to develop high-quality products and deliver the best services for our customers.
Your orders will be processed within 24 hours if the requested items are available in stock. We do not ship out orders on Friday. Orders received on Friday will be shipped out in the morning of the following Monday.
We diligently develop high quality products and strive to earn your satisfaction. If for any reason you are not satisfied with your purchases, please follow our Return Policy for product return or exchange.
If you know of any technology, product, or service development opportunities in the fields related, we would be very interested in hearing from you. Please Contact Us.