Stearoyl-CoA desaturase (SCD) is a highly expressed enzyme in primary human β-cells that is involved in PA metabolism and has a protective role against lipotoxicity in β-cells. SCD catalyzes insertion of the double bond at the delta-9 position of 12-19 carbon in saturated fatty acids, thereby converting them to MUFAs. SCD controls intracellular SFA/MUFA equilibrium, which is physiologically crucial for proper β-cell function given the cytotoxicity of long-chain SFAs higher than long-chain MUFAs.
It has been observed that SCD ablation is associated with β-cell failure and T2D development and results in lower GSIS, proliferation, and apoptosis induction in β-cells. Importantly, SCD gene expression is lower in β-cell enriched tissue from individuals with T2D compared with healthy donors. It has been proposed that, over time, in the course of T2D progression, SCD expression by β-cells is first induced during compensation in response to IR, and as the duration of diabetes increases, SCD expression decreases leading to a decline in β-cell function. Inhibition of SCD activity affects autophagosome-lysosome fusion through perturbations in cellular membrane integrity, leading to an aberrant stress response and β-cell failure and alters DNA methylation levels in 3T3-L1 adipocytes.
Xcess Biosciences Inc (XcessBio or Xbio) was founded in 2008 by scientists from academia and BioPharma industry with strong expertise in chemistry and biology. We are dedicated to develop high-quality products and deliver the best services for our customers.
Your orders will be processed within 24 hours if the requested items are available in stock. We do not ship out orders on Friday. Orders received on Friday will be shipped out in the morning of the following Monday.
We diligently develop high quality products and strive to earn your satisfaction. If for any reason you are not satisfied with your purchases, please follow our Return Policy for product return or exchange.
If you know of any technology, product, or service development opportunities in the fields related, we would be very interested in hearing from you. Please Contact Us.