Bmx is a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a ph-like domain that mediates membrane targeting by binding to phosphatidylinositol 3,4, 5-triphosphate (PIP3) and a SH2 domain that binds tyrosine to phosphorylate the protein and plays a role in signal transduction. The protein is involved in several signal transduction pathways, including the Stat pathway, and regulates the differentiation and tumorigenicity of several types of cancer cells. Bmx is characterized by the N-terminal pleckstrin homology domain and has been shown to be a downstream effector of phosphatidylinositol 3-kinase.
BMX-IN-1
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