GSNOR is an enzyme that governs tissue levels of GSNO and is widely expressed in many tissues, including lung. GSNOR activity is elevated in a murine model of allergic asthma. Mice deficient in GSNOR have increased concentrations of GSNO and SNO-proteins in their lungs and developed acute lung inflammation, but not airway hyperresponsiveness, after allergen sensitization and challenge. Moreover, new data in human studies suggest that potential host factors, which are related to GSNOR, may contribute to the airways hyperresponsiveness phenotype of asthma.
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