Mitochondrial Metabolism: An Approach for Disease Management covers mitotherapy from three combined perspectives, Pharmacology, Toxicology and Biochemistry.
Best known for their role in generating adenosine triphosphate (ATP) through oxidative phosphorylation, mitochondria are responsible for a wide variety of vital cellular processes including apoptosis, maintenance of calcium homeostasis, redox signaling, steroid synthesis, and lipid metabolism. The mitochondria are dynamic organelles, responding to changing cellular physiology, nutrient availability, and energy demands by changing in function as well as shape, size, distribution, and number. Given the many important roles of the mitochondria for normal cellular function, it is not surprising that mitochondrial dysfunction is involved in a wide variety of diseases and medical disorders.
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