ROCKs is the rho-associated coiled-coil kinase, known as Rho kinase, a member of the serine-threonine kinase family. RhoA and ROCK, members of the Ras homologous gene family, mediate many pathophysiological signals, including inducing cytoskeletal recombination, cell migration, adhesion, proliferation and differentiation, tissue contraction and growth. Therefore, ROCK inhibitors have potential applications in diseases including asthma, cancer, erectile dysfunction, glaucoma, insulin resistance, kidney failure, neuronal degeneration and osteoporosis.
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