Adiponectin receptors are G protein-coupled receptors (GPCRs) and are of two receptor subtypes, (AdipoR) 1 (375 aa, 42.4 kDa) and AdipoR2 (311 aa, 35.4 kDa). AdipoR 1 was cloned from a cDNA library of human skeletal muscle for globular adiponectin binding. AdipoR2 cloned only in yeast and is 67% amino acid homologous with AdipoR1. In both AdipoR1 and AdipoR2, the N-terminal domain exists in intracellular space and the C-terminal domain presents in the external region of cells. Usually, GPCR has an N-terminal extracellular domain. Therefore, AdipoRs are a new receptor group.
Gramine
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