ROS is a proto-oncogene receptor tyrosine kinase whose expression is severely restricted during development. ROS kinases are one of the last two orphan receptor tyrosine kinases. It is also thought that c-ROS genes may play a role in some cardiovascular diseases, and the fact that homozygous male mice targeted at C-ROS genes are healthy but infertile has inspired researchers to consider ROS suppression as a developmental approach. The new male contraceptive pill. The development of novel selective and potent inhibitors for ROS kinases, as well as new specific diagnostic methods for detecting ROS fusion proteins, raises the importance of targeting ROS mutations with these selective inhibitors as a novel approach for treating cancers carrying these genes.
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