SFRP1 (Secreted Frizzled Related Protein 1) is a Protein Coding gene. Diseases associated with SFRP1 include Chronic Apical Periodontitis and Glucocorticoid-Induced Osteoporosis. Among its related pathways are Signaling by Wnt and BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and heparin binding.
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity).
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