Pyroptosis is a type of regulated cell death that is primarily associated with the immune response as this cell death pathway is triggered by the presence of PAMPs or DAMPs. Morphologically, pyroptosis is characterized by features observed in apoptosis, such as nuclear condensation and DNA fragmentation, as well as features observed in necrosis, such as the formation of a pore on the plasma membrane followed by cellular swelling and subsequent rupture. There are two distinct pathways through which pyroptosis can occur: a canonical pathway involving the activation of CASP1 and a non-canonical pathway involving the activation of caspases 4/5/11 (CASP4/5/11).
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