LXR (Liver X receptor) is an important nuclear receptor in human body, which is ligand-dependent protein. As an integrator of hormones and nutritional signals, LXR regulates body metabolism mainly by regulating lipids and sugars, and is involved in the occurrence and development of type ii diabetes, obesity, cardiovascular disease, hyperlipidemia and other common metabolic diseases. Studies have proved that multiple LXR gene polymorphisms are closely related to the occurrence and development of metabolic diseases. Studying the pathological mechanism of LXR's involvement in metabolic diseases and exploring the correlation between LXR gene polymorphism and metabolic diseases is beneficial to detect and evaluate the risk of metabolic diseases from the genetic level, so as to realize early detection and prevention of the disease, improve the quality of life of patients with metabolic diseases and prolong their survival.
