BMX-IN-1


Catalog No. Size PriceQuantity
M10623-2 Solid 2 mg $120
M10623-10 Solid 10 mg $360

Description

BMX-IN-1 is a selective irreversible BMX inhibitor for prostate cancer. BMX-IN-1 can covalently modifies Cys496. BMX-IN-1 inhibits the proliferation of Tel-BMX-transformed Ba/F3 cells at two digit nanomolar concentrations but requires single digit micromolar concentrations to inhibit the proliferation of prostate cancer cell lines. MK2206, is able to potentiate BMX inhibitor's antiproliferation efficacy against prostate cancer cells.

Product information

CAS Number: 1431525-23-3

Molecular Weight: 524.59

Formula: C29H24N4O4S

Synonym:

BMX kinase inhibitor

N-(2-methyl-5-(9-(4-(methylsulfonamido)phenyl)-2-oxobenzo[h][1,6]naphthyridin-1(2H)-yl)phenyl)acrylamide

Chemical Name: N-{5-[9-(4-methanesulfonamidophenyl)-2-oxo-1H,2H-benzo[h]1,6-naphthyridin-1-yl]-2-methylphenyl}prop-2-enamide

Smiles: CC1=CC=C(C=C1NC(=O)C=C)N1C2=C(C=CC1=O)C=NC1=CC=C(C=C12)C1C=CC(=CC=1)NS(C)(=O)=O

InChiKey: SFMJNHNUOVADRW-UHFFFAOYSA-N

InChi: InChI=1S/C29H24N4O4S/c1-4-27(34)31-26-16-23(12-5-18(26)2)33-28(35)14-9-21-17-30-25-13-8-20(15-24(25)29(21)33)19-6-10-22(11-7-19)32-38(3,36)37/h4-17,32H,1H2,2-3H3,(H,31,34)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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