RP-64477

RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). RP-64477 inhibits ACAT activity with IC50 of 113 nM, 503 nM, and 180 nM in human intestinal (CaCo-2), hepatic (HepG2) and monocytic (THP-1) cell assays, respectively.

Product information

CAS Number: 135239-65-5

Molecular Weight: 498.72

Formula: C29H42N2O3S

Chemical Name: N'-Butyl-4-(decyloxy)-4'-(methylthio)-N,3'-bibenzamide

Smiles: CCCCCCCCCCOC1C=CC(=CC=1)C(=O)NC1=CC(=CC=C1SC)C(=O)NCCCC

InChiKey: OZMWNRSILHTVFV-UHFFFAOYSA-N

InChi: InChI=1S/C29H42N2O3S/c1-4-6-8-9-10-11-12-13-21-34-25-17-14-23(15-18-25)29(33)31-26-22-24(16-19-27(26)35-3)28(32)30-20-7-5-2/h14-19,22H,4-13,20-21H2,1-3H3,(H,30,32)(H,31,33)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO 100 mg/mL (200.51 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. A A Bello, et al. Biochem Pharmacol. 1996 Feb 23;51(4):413-21.

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