Synephrine(Oxedrine)

Synephrine (Oxedrine) is an α-adrenergic and β-adrenergic agonist derived from the Citrus aurantium, it has sympathomimetic and structural similarities to ephedra and ephedrine alkaloids[

Product information

CAS Number: 94-07-5

Molecular Weight: 167.21

Formula: C9H13NO2

Synonym:

S 38537-9

S38537-9

S-38537-9

Chemical Name: 4-[1-hydroxy-2-(methylamino)ethyl]phenol

Smiles: CNCC(O)C1=CC=C(O)C=C1

InChiKey: YRCWQPVGYLYSOX-UHFFFAOYSA-N

InChi: InChI=1S/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 33 mg/mLwarmed(197.35 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Synephrine is a compound commonly used for weight loss. Synephrine has gained significant popularity as an alternative to ephedrine. Products containing bitter orange or synephrine are suspected of causing adverse cardiovascular reactions. Synephrine can stimulate glucose consumption (Glut4-dependent glucose uptake) by stimulating AMPK activity, regardless of insulin-stimulated PI3 kinase-Akt activity in L6 skeletal muscle cells.

In Vivo:

LD50: Mice >1000mg/kg (s.c.)

References:

1. Hong NY, et al. Biochem Biophys Res Commun, 2012, 418(4), 720-724.
2. Haaz S, et al. Obes Rev, 2006, 7(1), 79-88.
3. Stohs SJ, et al. Int J Med Sci, 2012, 9(7), 527-538.

Products are for research use only. Not for human use.