PP2A Cancerous-IN-1 - CAS# 1403933-79-8


Catalog No. Size PriceQuantity
M17414-C Contact sales@xcessbio.com for quotation $100

Description

PP2A Cancerous-IN-1 is a strong and potent CIP2A (Cancerous inhibitor of PP2A) and p-Akt inhibitor. PP2A Cancerous-IN-1 shows the most potent antiproliferative activities.

Product information

CAS Number: 1403933-79-8

Molecular Weight: 488.54

Formula: C30H24N4O3

Chemical Name: N4-(3-ethynylphenyl)-6, 7-dimethoxy-N2-(4-phenoxyphenyl)quinazoline-2, 4-diamine

Smiles: COC1=CC2=NC(NC3C=CC(=CC=3)OC3C=CC=CC=3)=NC(NC3=CC(=CC=C3)C#C)=C2C=C1OC

InChiKey: UESUTKPLJQKPRL-UHFFFAOYSA-N

InChi: InChI=1S/C30H24N4O3/c1-4-20-9-8-10-22(17-20)31-29-25-18-27(35-2)28(36-3)19-26(25)33-30(34-29)32-21-13-15-24(16-14-21)37-23-11-6-5-7-12-23/h1,5-19H,2-3H3,(H2,31,32,33,34)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PP2A Cancerous-IN-1 (2.5 and 5 μM; 24 hours; SK-Hep-1 cells) reduces CIP2A expression and cell viability with a dose dependent manner and is more potent in its action than erlotinib. PP2A Cancerous-IN-1 (5 μM; 24 hours; SK-Hep-1 cells) induces cell apoptosis. PP2A Cancerous-IN-1 shows CIP2A inhibitory activity, reduces p-Akt level, induces PARP cleavage. PP2A Cancerous-IN-1 exhibits high potency with low IC50 values of 2.8 μM against HCC cells.

Products are for research use only. Not for human use.

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