Doxercalciferol-D3


Catalog No. Size PriceQuantity
M10219-2 Contact sales@xcessbio.com for quotation $100
M10219-10 Contact sales@xcessbio.com for quotation $100

Description

Doxercalciferol-D3 is the deuterated form of Doxercalciferol, which is a Vitamin D2 analog that acts as a vitamin D receptor activator (VDRA).

Product information

CAS Number: 2070009-32-2

Molecular Weight: 415.67

Formula: C28H44O2

Chemical Name: (1R, 3S, 5Z)-5-{2-[(1R, 3aS, 4E, 7aR)-1-[(2R, 3E, 5R)-5, 6-dimethylhept-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene](1-H)ethylidene}-4-(H)methylidenecyclohexane-1, 3-diol

Smiles: [2H]C([2H])=C1[C@@H](O)C[C@H](O)C/C/1=C(\[2H])/C=C1\CCC[C@]2(C)[C@H](CC[C@H]2\1)[C@H](C)/C=C/[C@H](C)C(C)C

InChiKey: HKXBNHCUPKIYDM-ZKEOFIQWSA-N

InChi: InChI=1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11+,23-12-/t19-,20+,24+,25+,26-,27-,28+/m0/s1/i5D2,12D

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Brown AJ, Ritter CS, Knutson JC, Strugnell SA. The vitamin D prodrugs 1alpha(OH)D2, 1alpha(OH)D3 and BCI-210 suppress PTH secretion by bovine parathyroid cells. Nephrol Dial Transplant. 2006 Mar;21(3):644-50.
  2. Noonan W, Koch K, Nakane M, Ma J, Dixon D, Bolin A, Reinhart G. Differential effects of vitamin D receptor activators on aortic calcification and pulse wave velocity in uraemic rats. Nephrol Dial Transplant. 2008 Dec;23(12):3824-30.
  3. Gran Sjdén. Effects of vitamin D. A comparison of 1 alpha OHD2 and 1 alpha OHD3 in rats.[J]. Acta Orthopaedica Scandinavica Supplementum, 1985, 217(1):1-84.

Products are for research use only. Not for human use.

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