EBE-A22


Catalog No. Size PriceQuantity
M10416-2 Solid 2 mg $90
M10416-10 Solid 10 mg $270

Description

EBE-A22 is a derivative of PD 153035. EBE-A22, has no effect on EGF-R TK but maintains a high cytotoxic profile. EBE-A22 binds to DNA and behave as typical intercalating agents. EBE-A22 unwinds supercoiled plasmid, stabilizes duplex DNA against heat denaturation, and produces negative CD and ELD signals, as expected for an intercalating agent. EBE-A22, but not PD153035, interacts preferentially with GC-rich sequences and discriminates against homooligomeric runs of A and T which are often cut more readily by the enzyme in the presence of the drug compared to the control.

Product information

CAS Number: 229476-53-3

Molecular Weight: 374.23

Formula: C17H16BrN3O2

Chemical Name: N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine

Smiles: COC1=CC2=C(N=CN=C2C=C1OC)N(C)C1=CC(Br)=CC=C1

InChiKey: IPWGDOZPSOZFOD-UHFFFAOYSA-N

InChi: InChI=1S/C17H16BrN3O2/c1-21(12-6-4-5-11(18)7-12)17-13-8-15(22-2)16(23-3)9-14(13)19-10-20-17/h4-10H,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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